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Peripheral nerve: Anatomy

Peripheral nerves have three layers of connective tissue:

  • Epineurium – is the outermost layer of connective tissue that is continuous with the dura mater. It also includes the connective tissue in between any fascicles (bundles) within the nerve.
  • Perineurium – is the connective tissue sheath that surrounds a fascicle of axons.
  • Endoneurium – is the delicate connective tissue fibers that surround individual axons.