- Released from zona glomerulosa of the adrenal glands
- Responsible for long term control (days) of blood pressure and plasma osmolarity
- Kidneys alter total body sodium and water balance to restore blood pressure to normal
- Increased release
- ACTH (anterior pituitary)
- Sympathetic stimulation (surgery, stress) → increased ACTH secretion
- Glucocorticoids → inhibit ACTH secretion
- Angiotensin II (renin angiotensin aldosterone system)
- Hyperkalemia
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