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The prevention of central line-associated bloodstream infections (CLABSI) has greatly improved with the implementation of Joint Commission-approved central line placement bundles combining hand hygiene, barrier precautions, chlorhexidine skin preparation, optimal catheter selection and site selection, sterile dressing, safe disposal of sharps, and daily review of line necessity with prompt removal of unnecessary central lines. When central lines are placed emergently, strict enforcement of central line bundles may not be possible. Moreover, central lines placed emergently are often placed in the femoral site which is associated with a higher rate of infection. The Joint Commission as well as other professional societies recommend replacing central venous catheters placed under emergent conditions within 24 hours at a different site. Sterile rewiring of central venous catheters does not fully reduce the risk of CLABSI and may introduce organisms into the bloodstream from the catheter or catheter site despite sterile conditions.